Adagio |

Our mission is to provide an effective long-term solution for the global coronavirus challenge.

Highly potent broadly neutralizing antibodies offer the best possibility to resolve the current COVID19 pandemic while also preparing for future outbreaks of related viruses.

Our best-in-class broadly neutralizing antibodies can meet the current and future challenges posed by the spillover of coronaviruses into humans.

Our mission is to provide an effective long-term solution for the global coronavirus challenge.

Highly potent broadly neutralizing antibodies offer the best possibility to squelch the current COVID19 pandemic while also preparing for future outbreaks of related viruses.

Our best in class broadly neutralizing antibodies can meet the current and future challenges posed by the spillover of coronaviruses into humans.

About Us

Adagio is developing best-in-class antibodies that can broadly neutralize SARS-CoV-2, SARS-CoV-1 and additional potentially emergent coronaviruses. We believe our antibodies will match or exceed the potency and coverage of conventional SARS-CoV-2 antibody programs, and can be used as both therapeutic and durable prophylactic treatments. Our candidates are engineered using best-in-industry antibody discovery capabilities and are designed to maximize potency and duration of effect. Our portfolio includes multiple, non-competing antibodies with distinct binding targets, enabling a strategy that can avoid viral escape. Our lead program is expected to enter the clinic by the end of 2020.

Management Team

Tillman Gerngross, Ph.D.

Co-Founder & CEO

Halley Gilbert

Chief Operating Officer & Chief Business Officer

Laura Walker, Ph.D.

Co-Founder & Chief Scientific Officer

Ellie Hershberger, PharmD

Chief Development Officer

Becky Dabora, Ph.D.

Chief Technology & Manufacturing Officer

Paul Ambrose, PharmD, FIDSA

Chief Translational Medicine Officer

Lynn Connolly, MD, Ph.D.

Chief Medical Officer

MEDIA & PUBLICATIONS

PRESS RELEASES

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Adagio Therapeutics Launches with $50M Series A Financing to Advance the Development of Best-in-Class, Broadly Neutralizing Antibodies for Coronavirus Treatment and Prophylaxis

PUBLICATIONS

Relevant Publications by
Adagio Scientists:

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Wec AZ et al. Broad neutralization of SARS-related antibodies by human monoclonal antibodies. Science. 2020 Jun 15.

Science

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Wec AZ et al. Longitudinal dynamics of the human B cell response to the yellow fever 17D vaccine. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6675-6685.

Proceedings of the National Academy of Sciences (PNAS)

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Shehata L et al. Systematic comparison of respiratory syncytial virus-induced memory B cell responses in two anatomical compartments. Nat Commun. 2019 Mar 8; 10(1):1126.

Nature Communications

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West BR et al. Structural basis of broad ebolavirus neutralization by a human survivor antibody. Nat Struct Mol Biol. 2019 Mar; 26(3):204-212.

Nature Structural and Molecular Biology

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Bornholdt ZA et al. A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates. Cell Host Microbe. 2019 Jan 9; 25(1):49-58.e5.

Cell Host and Microbe

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Wec AZ et al. Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection. Cell Host Microbe. 2019 Jan 9; 25(1):39-48.e5.

Cell Host and Microbe

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Saphire EO et al. Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection (2018). Cell. Aug 09; 174(4):938-952.

Cell

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Goodwin E et al. Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation (2018). Immunity. Feb 20; 48(2):339-349

Immunity

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Walker LM et al. Passive immunotherapy of viral infections: ‘super-antibodies’ enter the fray (2018). Nat Rev Immunol. May; 18(5):297-308.

Nature Reviews Immunology

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Rogers TF et al. Zika virus activates de novo and cross-reactive memory B cell responses in dengue-experienced donors (2017). Sci Immunol. Aug 18; 2(14).

Science Immunology

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Wec AZ et al. Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses (2017). Cell. May 18; 169(5):878-890.

Cell

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Gilman MS et al. Rapid profiling of RSV antibody repertoires from the memory B cells of naturally infected adult donors (2016). Sci Immunol. Dec 16; 1(6).

Science Immunology

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Badarau A et al. Context matters: The importance of dimerization-induced conformation of the LukGH leukocidin of Staphylococcus aureus for the generation of neutralizing antibodies (2016). MAbs. Jul 28:0.

mAbs

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Bornholdt ZA et al. Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak (2016). Science. Mar 4;351(6277):1078-83.

Science

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Walker LM et al. Broad neutralization coverage of HIV by multiple highly potent antibodies (2011). Nature. Aug 17;477(7365):466-470.

Nature

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Walker LM et al. Rational antibody-based HIV-1 vaccine design: current approaches and future directions (2010). Curr Opin Immunol. Jun; 22(3):358-66.

Science Direct

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Walker LM et al. Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target (2009). Science. 326(5950):285-9.

Science

RELEVANT RESOURCES

The Case for Monoclonal antibodies:

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Antibodies Can Be the Bridge to a Vaccine

WSJ

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Even without a Covid-19 vaccine, there’s reason for hope

CNN

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Antibody Drugs Could Help Curb the Pandemic. What Investors Need to Know.

Barron’s

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Which drug developers offer Trump a quick, game-changing ‘solution’ as the pandemic roars back? Eli Lilly and AbCellera look to break out of the pack

Endpoints

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OWS shifts spotlight to drugs to fight Covid-19, handing Regeneron $450M to begin large scale manufacturing in the US

Endpoints

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The U.S. Is Buying $450M of Regeneron’s Experimental Covid-19 Antibody. Its Stock Is Jumping.

Barron’s

For SARS-CoV-2 Efficacious Vaccines may be more elusive than expected:

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Coronavirus herd immunity may be ‘unachievable’ after study suggests antibodies disappear after weeks in some people

Business Insider

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