About Us
Adagio is developing best-in-class antibodies that can broadly neutralize SARS-CoV-2, SARS-CoV-1 and additional potentially emergent coronaviruses. We believe our antibodies will match or exceed the potency and coverage of conventional SARS-CoV-2 antibody programs, and can be used as both therapeutic and durable prophylactic treatments. Our candidates are engineered using best-in-industry antibody discovery capabilities and are designed to maximize potency and duration of effect. Our portfolio includes multiple, non-competing antibodies with distinct binding targets, enabling a strategy that can avoid viral escape. Our lead program is expected to enter the clinic by the end of 2020.
Management Team
Tillman Gerngross, Ph.D.
Co-Founder & CEO
Halley Gilbert
Chief Operating Officer & Chief Business Officer
Laura Walker, Ph.D.
Co-Founder & Chief Scientific Officer
Ellie Hershberger, PharmD
Chief Development Officer
Becky Dabora, Ph.D.
Chief Technology & Manufacturing Officer
Paul Ambrose, PharmD, FIDSA
Chief Translational Medicine Officer
Lynn Connolly, MD, Ph.D.
Chief Medical Officer
Eric Kimble, M.B.A.
Chief Commercial Officer
MEDIA & PUBLICATIONS
PRESS RELEASES
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9.28.2020
Adagio Named a Winner of Fierce Biotech’s “Fierce 15 2020”
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9.09.2020
Adagio Therapeutics Strengthens Management Team with Appointments of Eric Kimble as Chief Commercial Officer and Ed Campanaro as SVP of Clinical Operations
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8.24.2020
Adagio Therapeutics Announces Appointment of Howard Mayer, M.D., to its Board of Directors
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7.16.2020
Adagio Therapeutics Launches with $50M Series A Financing to Advance the Development of Best-in-Class, Broadly Neutralizing Antibodies for Coronavirus Treatment and Prophylaxis
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PUBLICATIONS
Relevant Publications by
Adagio Scientists:
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Wec AZ et al. Broad neutralization of SARS-related antibodies by human monoclonal antibodies. Science. 2020 Jun 15.
Science
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Wec AZ et al. Longitudinal dynamics of the human B cell response to the yellow fever 17D vaccine. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6675-6685.
Proceedings of the National Academy of Sciences (PNAS)
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Shehata L et al. Systematic comparison of respiratory syncytial virus-induced memory B cell responses in two anatomical compartments. Nat Commun. 2019 Mar 8; 10(1):1126.
Nature Communications
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West BR et al. Structural basis of broad ebolavirus neutralization by a human survivor antibody. Nat Struct Mol Biol. 2019 Mar; 26(3):204-212.
Nature Structural and Molecular Biology
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Bornholdt ZA et al. A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates. Cell Host Microbe. 2019 Jan 9; 25(1):49-58.e5.
Cell Host and Microbe
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Wec AZ et al. Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection. Cell Host Microbe. 2019 Jan 9; 25(1):39-48.e5.
Cell Host and Microbe
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Saphire EO et al. Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection (2018). Cell. Aug 09; 174(4):938-952.
Cell
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Goodwin E et al. Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation (2018). Immunity. Feb 20; 48(2):339-349
Immunity
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Walker LM et al. Passive immunotherapy of viral infections: ‘super-antibodies’ enter the fray (2018). Nat Rev Immunol. May; 18(5):297-308.
Nature Reviews Immunology
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Rogers TF et al. Zika virus activates de novo and cross-reactive memory B cell responses in dengue-experienced donors (2017). Sci Immunol. Aug 18; 2(14).
Science Immunology
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Wec AZ et al. Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses (2017). Cell. May 18; 169(5):878-890.
Cell
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Gilman MS et al. Rapid profiling of RSV antibody repertoires from the memory B cells of naturally infected adult donors (2016). Sci Immunol. Dec 16; 1(6).
Science Immunology
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Badarau A et al. Context matters: The importance of dimerization-induced conformation of the LukGH leukocidin of Staphylococcus aureus for the generation of neutralizing antibodies (2016). MAbs. Jul 28:0.
mAbs
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Bornholdt ZA et al. Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak (2016). Science. Mar 4;351(6277):1078-83.
Science
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Walker LM et al. Broad neutralization coverage of HIV by multiple highly potent antibodies (2011). Nature. Aug 17;477(7365):466-470.
Nature
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Walker LM et al. Rational antibody-based HIV-1 vaccine design: current approaches and future directions (2010). Curr Opin Immunol. Jun; 22(3):358-66.
Science Direct
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Walker LM et al. Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Target (2009). Science. 326(5950):285-9.
Science
RELEVANT RESOURCES
Adagio Perspective
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Investors think Lebanon biotech startup may be a winner in the fight against the coronavirus
Valley News
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An Audience With: Tillman Gerngross
Nature
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The Case for Antibodies
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It Will Take More Than a Vaccine to Beat COVID-19
The New Yorker
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Antibody drugs could be one of the best weapons against Covid-19. But will they matter?
Stat
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Antibody therapies could be a bridge to a coronavirus vaccine — but will the world benefit?
Nature
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Antibody Drugs Could Help Curb the Pandemic. What Investors Need to Know.
Barron’s
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Why Vaccines May Not Be Enough
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Peter Marks on Covid-19 vaccine efficacy, EUAs and challenge trials
Endpoints
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Coronavirus herd immunity may be ‘unachievable’ after study suggests antibodies disappear after weeks in some people
Business Insider
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Coronavirus antibodies may disappear after mere months in some people, research shows. But it’s not necessarily a reason to panic.
Yahoo!
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After Trumps’ diagnosis: Vaccine or not, COVID-19 isn’t going away
USA TODAY
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COVID research updates: The immune trait that could allow viral reinfection
Nature
INVESTORS
Board of Directors
Co-Founder & Chair of the Board, Adagio
Chief Executive Officer, Xilio Therapeutics
Co-Founder & CEO of Adagio and
Adimab, LLC
Partner, Polaris Partners
Partner, Mithril Capital
Marc Elia
Founder, M28 Capital
General Counsel, Adimab, LLC
Howard Mayer, MD
Executive Vice President, Head of Research and Development, Ipsen Pharmaceuticals